Iowa State vs. Texas Tech prediction, pick, odds, spread: No. 16 Red Raiders face surging No. 4 Cyclones
Iowa State faces Texas Tech on Saturday in a clash of top 25 teams
tamil yogi

No. 16 Texas Tech travels to Ames, Iowa, on Saturday to face No. 4 Iowa State on CBS. It will be the 47th all-time meeting between the Big 12 rivals, with Iowa State holding a 24-22 edge. This is the teams’ only regular-season matchup, though they could meet again in next month’s Big 12 Tournament.
Iowa State is coming off a win over Utah and has won eight of its past 10 games. The Cyclones enter the weekend in a four-way tie for second place in the Big 12 standings along with Houston, Texas Tech and Kansas — all of which are two games behind Arizona.
Texas Tech continues to adjust without star forward JT Toppin, who tore his ACL earlier this month against Arizona State. Toppin was a potential National Player of the Year candidate before the season-ending injury. The Red Raiders are 2-0 since then, with wins over Kansas State and Cincinnati.
Here is everything you need to know ahead of Texas Tech and Iowa State this weekend.
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Iowa State dominant at home: Iowa State has been nearly unbeatable at Hilton Coliseum. The Cyclones are 15-0 at home this season and are the only Big 12 team without a loss on their home floor. Their last home defeat came March 4, 2025, against BYU — nearly a calendar year ago. Iowa State is 48-2 at home over the past three seasons.
Can Texas Tech pull the upset without Toppin? Losing a player of Toppin’s caliber lowered Texas Tech’s ceiling. Still, the Red Raiders’ gritty style makes them a difficult matchup in March. It helps that Christian Anderson has emerged as an All-American-level performer. He will need to carry much of the offensive load down the stretch if Texas Tech hopes to spring the upset.
Big 12 title race implications: The winner will remain in contention for a share of the Big 12 regular-season title and gain a valuable boost in conference tournament seeding. At minimum, the winner could position itself for the No. 2 seed. The top four teams in the standings receive a double-bye in the Big 12 Tournament. Iowa State closes the regular season against Arizona and Arizona State, while Texas Tech faces TCU and BYU.
Date: Saturday, Feb. 28 | Time: 4 p.m. ET
Location: Hilton Coliseum — Ames, Iowa
TV: CBS | Live stream: CBSSports.com, CBS Sports App
Streaming on Paramount+ Premium
Iowa State has a unique home court advantage. The Cyclones have quite literally been unbeatable inside Hilton Coliseum this season. I don’t expect that to change on Saturday. If Texas Tech still had Toppin in the line, I would lean the Red Raiders covering the spread. However, that is not the case. I expect Iowa State to win by double digits on Saturday. Pick: Iowa State -7
Who will win and cover in every college basketball game? Visit SportsLine to get picks from the model that simulates each game 10,000 times and is up more than $1,200 for $100 players on its top-rated spread picks the past six years.
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